Cholestest LDL

Cholestest LDL is a liquid reagent for the measurement of LDL-cholesterol concentrations using differences in affinity between lipoproteins and detergents. It requires no fractionation steps and can be used on various automated analyzers. It also shows a high correlation with the ultracentrifugation method.

  • Use of the direct method requires no complex operations
  • High correlation with the ultracentrifugation method
  • Liquid reagent applicable to various automated analyzers
  • Not influenced by chyle (up to 1500 mg/dl of triglyceride)
  • *This package insert follows the Pharmaceuticals, Medical devices and Other Therapeutic Products Act of Japan.


*Read carefully the package insert before use.

Reference Data (1)

Control Your LDL Cholesterol Level

Patients with diabetes have a high rate of macrovascular diseases, such as coronary artery disease. According to results of a large-scale intervention test, not only blood glucose control but also lipid control are important in preventing patients with diabetes from developing macrovascular diseases. The major cause of death in patients with type 2 diabetes is not the three major complications (retinopathy, nephropathy and peripheral nerve disorder) but macrovascular diseases.

Risk factors for coronary artery diseases for patients with type 2 diabetes (according to UKPDS*)

  • No. 1 factor : LDL cholesterol
  • No. 2 factor : HDL cholesterol
  • No. 3 factor : HbA1c

According to the UKPDS, LDL cholesterol and HDL cholesterol rank number 1 and 2, respectively, as risk factors for coronary artery diseases in patients with type 2 diabetes. At the very least, the study suggests that hyperlipidemia has a greater effect on longevity than hyperglycemia.

Seven-year icidence rates of myocardial infarction (%)

The relationship between diabetes and myocardial infarction is shown above. According to the data, diabetes itself is a great risk for myocardial infarction; the risk level is nearly the same as that for nondiabetic patients with a history of myocardial infarction.

  • *United Kingdom Prospective Diabetes Study

Reagent Cholestest LDL for direct method for LDL cholesterol measurement

Comparison between ultracentrifugation and direct methods

Comparison between ultracentrifugation and direct methods
Comparison between ultracentrifugation and direct methods

Sixty to seventy percent of patients with diabetes develop hyperlipemia (diabetes complicated hyperlipemia), and develop hypertriglyceridemia associated with an increase in remnants. Cholestest LDL is unaffected by high levels of TG, and thereby allows accurate measurement in patients with diabetic hyperlipemia or even in samples collected after meals.

About test items

LDL-Cholesterol, the so-called “bad” cholesterol, is said to be contained in large quantities in blood of patients with cardiac or cerebral vascular diseases, and increases with age.

Age-specific LDL-Cholesterol Level
History of LDL-Cholesterol

“Cholestest” is a trademark or registered trademark of SEKISUI MEDICAL CO., LTD. in Japan and/or other countries.

Cholestest LDL

Additional information

Cholestest LDL|Enzyme Solution 1

2×60mL, Storage: 2-10℃

Cholestest LDL|Enzyme Solution 2

2×20mL, Storage: 2-10℃

Cholestest N Calibrator*

3×2.0mL, Storage: 2-10℃

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